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Post-Doctoral Researcher: Protein Design & Functional Mapping (JR00006560)


Last Updated: 1/17/21

Job Description

Post-Doctoral Researcher: Protein Design & Functional Mapping

The Protein Therapeutics group is seeking a talented and experienced computational modeler / protein engineer to contribute to our efforts in Global Therapeutics Research at Zoetis. The Protein Therapeutics group partners with therapeutic areas and project teams to design and engineer novel biotherapeutics and build robust testing funnels for a variety of therapeutic approaches to improve diseases in companion animals as well as livestock species.

The successful candidate should have knowledge of antibodies and/or protein interactions and relevant experience with machine learning & bioinformatics approaches, in silico protein homology models, protein docking, and epitope mapping. Experience with and understanding of peptide design, protein design and engineering, biochemistry, and protein characterization is preferred. Excellent communication, organizational and interpersonal skills are essential. Some travel required depending on location of candidate.


  • Integration of large datasets into protein design algorithms
  • Protein and antibody in silico design and structural mapping
  • Epitope mapping and immunogen design
  • Antibody optimization and affinity maturation using rational design techniques
  • Collaborate across multiple scientific disciplines to understand mechanistic biology
  • Directly communicate with external partners for collaborations and outsourcing.


  • Educational background: Ph.D. in engineering, computer science, immunology, biochemistry, or related field.
  • Training or experience in biological sciences focusing on protein design algorithms and optimization, protein engineering and protein modeling.
  • Machine learning and bioinformatics with an emphasis on protein sequence-function and structure-function relationships preferred.
  • Expertise in protein modeling techniques including homology modeling, epitope/paratope mapping, in silico protein optimization, and immunogen design.
  • Exposure to affinity maturation & antibody optimization approaches preferred.
  • Understanding of protein biochemistry and stability is a plus.
  • Self-starter, able to prioritize work and work efficiently, design experiments with minimal supervision, and able work across teams remotely and face-to-face.
  • Excellent verbal/written communication, organizational and interpersonal skills
  • Computer skills required: Microsoft Word, Excel, Outlook, BLAST, Vector NTI or equivalent, protein modeling software (MOE, Rosetta, etc.)


• Work environment: The placement of this position will be in Boulder, CO. This person will be expected to travel occasionally to R&D Headquarters (Kalamazoo, MI).

Full time



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Company Details


Parsippany, New Jersey, United States

Zoetis discovers, develops, manufactures and commercializes medicines, vaccines and diagnostic products, which are complemented by biodevices, genetic tests and precision livestock farming. Zoetis serves veterinarians, livestock producers and people who raise and care for farm and companion animals in more than 100 countries.