(Archived) Bioanalytical Scientist

Zoetis Veterinary Medicine Research and Development (VMRD) seeks an enthusiastic colleague for a challenging and fast-paced position in research and development of veterinary medicines in Kalamazoo, Michigan. The candidate will develop and validate analytical methods to measure concentrations of veterinary pharmaceuticals in plasma/serum, tissues, excreta, and other matrices to investigate the safety and efficacy of veterinary products. The candidate will collaborate extensively with target animal safety, toxicology, pharmacokinetics, environmental, clinical, and regulatory scientists as part of multidisciplinary teams. Duties will focus on laboratory work in the first 3 years which could be expanded to broader responsibilities based upon interest, ability, and business needs.

Responsibilities include:

• Developing and validating analytical methods to quantify residues of veterinary pharmaceuticals and biotherapeutics in blood/plasma, tissues, excreta, and other matrices at the mg/g to pg/g level.
• Providing bioanalytical support for projects.
• Conducting in vitro and in vivo studies and profiling samples from radiolabel studies in the future.
• Serving as Study Director, Principal Investigator, or Contributing Scientist for GLP and GCP studies.
• Placing and monitoring studies conducted at Contract Research Organizations.
• Writing or contributing to study reports and regulatory submissions.
• Occasional domestic or international travel: usually <5% annually depending upon nature and stage of project.

Minimum skills, education, attributes:

• BS or MS in chemistry, biochemistry, biology, pharmacy/pharmaceutics, or related field.
• At least 5 years of experience in the veterinary or human pharmaceutical or agricultural/food industries.
• Experience developing and validating quantitative methods for compounds in complex matrices by UPLC/HPLC-MS/MS and other methods.
• Experience with chromatography and sample preparation methodologies for biological samples.
• Excellent organizational and communication abilities (verbal and written English).
• Ability to work in a collaborative and dynamic team environment in a global company.
• Other attributes: Problem solving, judgment, perseverance, planning, adaptability, and communication skills.

Desirable skills, education, and attributes:

• Working a regulated environment (e.g., GLP).
• Working with radioisotopes (14C, 3H)
• Metabolite profiling and/or structure elucidation of metabolites by NMR, mass spectrometry, etc.
• In vitro metabolism or in vivo ADME studies.
• Scientific writing such as protocols, reports, journal articles, etc.
• Analysis of biotherapeutics (monoclonal antibodies, endogenous or recombinant proteins) in biological matrices.
• E-notebooks (e.g., IDBS Biobook), LIMS (e.g., WATSON), laboratory automation and liquid-handling systems (e.g., Hamilton MICROLAB STAR).

Familiar with regulatory requirements (VICH/ICH, FDA/CVM, OECD) for human or veterinary pharmaceuticals